Effect of Paclitaxel in the Water Dynamics of MCF-7 Breast Cancer Cells Revealed by Dielectric Spectroscopy

Research output: Contribution to journal › Journal article › Research › peer-review

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Effect of Paclitaxel in the Water Dynamics of MCF-7 Breast Cancer Cells Revealed by Dielectric Spectroscopy. / Martins, Murillo L.; Bordallo, Heloisa N.; Arrese-Igor, Silvia; Alegria, Angel; de Leon, Juan Colmenero.

In: ACS Omega, Vol. 5, No. 30, 04.08.2020, p. 18602-18607.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Martins, ML, Bordallo, HN, Arrese-Igor, S, Alegria, A & de Leon, JC 2020, 'Effect of Paclitaxel in the Water Dynamics of MCF-7 Breast Cancer Cells Revealed by Dielectric Spectroscopy', ACS Omega, vol. 5, no. 30, pp. 18602-18607. https://doi.org/10.1021/acsomega.0c00897

APA

Martins, M. L., Bordallo, H. N., Arrese-Igor, S., Alegria, A., & de Leon, J. C. (2020). Effect of Paclitaxel in the Water Dynamics of MCF-7 Breast Cancer Cells Revealed by Dielectric Spectroscopy. ACS Omega, 5(30), 18602-18607. https://doi.org/10.1021/acsomega.0c00897

Vancouver

Martins ML, Bordallo HN, Arrese-Igor S, Alegria A, de Leon JC. Effect of Paclitaxel in the Water Dynamics of MCF-7 Breast Cancer Cells Revealed by Dielectric Spectroscopy. ACS Omega. 2020 Aug 4;5(30):18602-18607. https://doi.org/10.1021/acsomega.0c00897

Author

Martins, Murillo L. ; Bordallo, Heloisa N. ; Arrese-Igor, Silvia ; Alegria, Angel ; de Leon, Juan Colmenero. / Effect of Paclitaxel in the Water Dynamics of MCF-7 Breast Cancer Cells Revealed by Dielectric Spectroscopy. In: ACS Omega. 2020 ; Vol. 5, No. 30. pp. 18602-18607.

Bibtex

@article{5881505ce0dd40a083d94d22b26ce36e,
title = "Effect of Paclitaxel in the Water Dynamics of MCF-7 Breast Cancer Cells Revealed by Dielectric Spectroscopy",
abstract = "Using dielectric spectroscopy experiments performed at multiple temperatures and frequency ranges, we demonstrate how the chemotherapy drug paclitaxel changes the dynamic properties of water in a breast cancer cell line (MCF-7). From the measured data, we present evidence that treatment with paclitaxel leads to a slight increase in activation energy in a relaxation related to bulk-like water. More importantly, we also observe that paclitaxel changes the constraining imposed by the biological interfaces on hydration water, whose single-particle dynamics becomes slower and with higher activation energy. These variations are only observable after freezing the dynamics from other cellular components, such as proteins and DNAs, regardless of the state of the cells, that is, treated or not treated or even if the cells are no longer viable. Therefore, changes in water dynamics could be detected prior to those related to the global dynamics within the cellular environment.",
keywords = "INTRACELLULAR WATER",
author = "Martins, {Murillo L.} and Bordallo, {Heloisa N.} and Silvia Arrese-Igor and Angel Alegria and {de Leon}, {Juan Colmenero}",
year = "2020",
month = aug,
day = "4",
doi = "10.1021/acsomega.0c00897",
language = "English",
volume = "5",
pages = "18602--18607",
journal = "ACS Omega",
issn = "2470-1343",
publisher = "ACS Publications",
number = "30",

}

RIS

TY - JOUR

T1 - Effect of Paclitaxel in the Water Dynamics of MCF-7 Breast Cancer Cells Revealed by Dielectric Spectroscopy

AU - Martins, Murillo L.

AU - Bordallo, Heloisa N.

AU - Arrese-Igor, Silvia

AU - Alegria, Angel

AU - de Leon, Juan Colmenero

PY - 2020/8/4

Y1 - 2020/8/4

N2 - Using dielectric spectroscopy experiments performed at multiple temperatures and frequency ranges, we demonstrate how the chemotherapy drug paclitaxel changes the dynamic properties of water in a breast cancer cell line (MCF-7). From the measured data, we present evidence that treatment with paclitaxel leads to a slight increase in activation energy in a relaxation related to bulk-like water. More importantly, we also observe that paclitaxel changes the constraining imposed by the biological interfaces on hydration water, whose single-particle dynamics becomes slower and with higher activation energy. These variations are only observable after freezing the dynamics from other cellular components, such as proteins and DNAs, regardless of the state of the cells, that is, treated or not treated or even if the cells are no longer viable. Therefore, changes in water dynamics could be detected prior to those related to the global dynamics within the cellular environment.

AB - Using dielectric spectroscopy experiments performed at multiple temperatures and frequency ranges, we demonstrate how the chemotherapy drug paclitaxel changes the dynamic properties of water in a breast cancer cell line (MCF-7). From the measured data, we present evidence that treatment with paclitaxel leads to a slight increase in activation energy in a relaxation related to bulk-like water. More importantly, we also observe that paclitaxel changes the constraining imposed by the biological interfaces on hydration water, whose single-particle dynamics becomes slower and with higher activation energy. These variations are only observable after freezing the dynamics from other cellular components, such as proteins and DNAs, regardless of the state of the cells, that is, treated or not treated or even if the cells are no longer viable. Therefore, changes in water dynamics could be detected prior to those related to the global dynamics within the cellular environment.

KW - INTRACELLULAR WATER

U2 - 10.1021/acsomega.0c00897

DO - 10.1021/acsomega.0c00897

M3 - Journal article

C2 - 32775862

VL - 5

SP - 18602

EP - 18607

JO - ACS Omega

JF - ACS Omega

SN - 2470-1343

IS - 30

ER -

ID: 248234019