Context. The star-formation rate (SFR) quantitatively describes the star-formation process in galaxies throughout cosmic history. Current ways to calibrate this rate do not usually employ observational methods accounting for the low-mass end of stellar populations as their signatures are too weak. Aims. Accessing the bulk of protostellar activity within galactic star-forming regions can be achieved by tracing signposts of ongoing star formation. One such signpost is molecular outflows, which are particularly strong at the earliest stages of star formation. These outflows are bright in molecular emission, which is readily observable. We propose to utilize the protostellar outflow emission as a tracer of the SFR. Methods. In this work, we introduce a novel version of the galaxy-in-A-box model, which can be used to relate molecular emission from star formation in galaxies with the SFR. We measured the predicted para-water emission at 988 GHz (which is particularly bright in outflows) and corresponding SFRs for galaxies with LFIR = 108 1011L· in a distance-independent manner, and compared them with expectations from observations. Results. We evaluated the derived results by varying star-forming parameters, namely the star formation efficiency, the free-fall time scaling factor, and the initial mass function. We observe that for the chosen water transition, relying on the current Galactic observations and star formation properties, we are underestimating the total galactic emission, while overestimating the SFRs, particularly for more starburst-like configurations. Conclusions. The current version of the galaxy-in-A-box model only accounts for a limited number of processes and configurations, that is, it focuses on ongoing star formation in massive young clusters in a spiral galaxy. Therefore, the inferred results, which underestimate the emission and overestimate the SFR, are not surprising: known sources of emission are not included in the model. To improve the results, the next version of the model needs to include a more detailed treatment of the entire galactic ecosystem and other processes that would contribute to the emission. Thus, the galaxy-in-A-box model is a promising step toward unveiling the star-forming properties of galaxies across cosmic time.