Geometric uncertainties in voluntary deep inspiration breath hold radiotherapy for locally advanced lung cancer
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Geometric uncertainties in voluntary deep inspiration breath hold radiotherapy for locally advanced lung cancer. / Josipovic, Mirjana; Persson, Gitte F; Dueck, Jenny; Bangsgaard, Jens Peter; Westman, Gunnar; Specht, Lena; Aznar, Marianne C.
In: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, Vol. 118, No. 3, 03.2016, p. 510-514.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Geometric uncertainties in voluntary deep inspiration breath hold radiotherapy for locally advanced lung cancer
AU - Josipovic, Mirjana
AU - Persson, Gitte F
AU - Dueck, Jenny
AU - Bangsgaard, Jens Peter
AU - Westman, Gunnar
AU - Specht, Lena
AU - Aznar, Marianne C
N1 - Corrigendum to; vol 133, 10.1016/j.radonc.2019.01.025
PY - 2016/3
Y1 - 2016/3
N2 - BACKGROUND AND PURPOSE: Deep inspiration breath hold (DIBH) increases lung volume and can potentially reduce treatment-related toxicity in locally advanced lung cancer. We estimated geometric uncertainties in visually guided voluntary DIBH and derived the appropriate treatment margins for different image-guidance strategies.MATERIAL AND METHODS: Seventeen patients were included prospectively. An optical marker-based respiratory monitoring with visual guidance enabled comfortable DIBHs, adjusted to each patient's performance. All patients had three consecutive DIBH CTs at each of the treatment fractions 2, 16 and 31. DIBH reproducibility was evaluated as inter- and intra-fractional variations in lung volume, tumour position and differential motion between primary tumour and mediastinal lymph nodes.RESULTS: Lung volume increased by median 60% in DIBH. Inter- and intra-fractional lung volume variations were median 2.1% and 1.1%, respectively. Inter- and intra-fractional uncertainties in 3D tumour position were 4.8 ± 2.8 mm and 1.7 ± 1.4 mm (mean ± SD). Inter- and intra-fractional differential motion was 4.8 ± 3.3 mm and 0.0 ± 1.1 mm.CONCLUSIONS: For single targets, visually guided voluntary DIBH radiotherapy is highly reproducible provided an image-guidance strategy with tumour registration is performed. If the primary tumour is separated from the mediastinal lymph nodes, inter-fractional differential motion remains a challenge and margins must be adapted to reflect the image registration strategy.
AB - BACKGROUND AND PURPOSE: Deep inspiration breath hold (DIBH) increases lung volume and can potentially reduce treatment-related toxicity in locally advanced lung cancer. We estimated geometric uncertainties in visually guided voluntary DIBH and derived the appropriate treatment margins for different image-guidance strategies.MATERIAL AND METHODS: Seventeen patients were included prospectively. An optical marker-based respiratory monitoring with visual guidance enabled comfortable DIBHs, adjusted to each patient's performance. All patients had three consecutive DIBH CTs at each of the treatment fractions 2, 16 and 31. DIBH reproducibility was evaluated as inter- and intra-fractional variations in lung volume, tumour position and differential motion between primary tumour and mediastinal lymph nodes.RESULTS: Lung volume increased by median 60% in DIBH. Inter- and intra-fractional lung volume variations were median 2.1% and 1.1%, respectively. Inter- and intra-fractional uncertainties in 3D tumour position were 4.8 ± 2.8 mm and 1.7 ± 1.4 mm (mean ± SD). Inter- and intra-fractional differential motion was 4.8 ± 3.3 mm and 0.0 ± 1.1 mm.CONCLUSIONS: For single targets, visually guided voluntary DIBH radiotherapy is highly reproducible provided an image-guidance strategy with tumour registration is performed. If the primary tumour is separated from the mediastinal lymph nodes, inter-fractional differential motion remains a challenge and margins must be adapted to reflect the image registration strategy.
KW - Journal Article
UR - http://10.1016/j.radonc.2019.01.025
U2 - 10.1016/j.radonc.2015.11.004
DO - 10.1016/j.radonc.2015.11.004
M3 - Journal article
C2 - 26631647
VL - 118
SP - 510
EP - 514
JO - Radiotherapy & Oncology
JF - Radiotherapy & Oncology
SN - 0167-8140
IS - 3
ER -
ID: 164510766