The recent commissioning of the full DeepCore sub-array, a low-energy extension of the IceCube neutrino observatory, offers opportunities for neutrino physics in the energy region of 10 GeV to 1 TeV. The improved energy reach, use of the surrounding IceCube detector as an active veto and immense size of DeepCore will produce one of the largest all-sky neutrino datasets ever acquired. DeepCore will provide sensitivity to neutrinos from possible neutralino dark matter annihilations in the Earth, Sun and galactic center, down to neutralino masses in the region of ~ 50 GeV. Tens of thousands of atmospheric neutrinos will be detected annually after oscillating over a baseline of up to one Earth diameter, opening the possibilities for muon neutrino disappearance and tau neutrino appearance measurements.