The Gompertz Law emerges naturally from the inter-dependencies between sub-components in complex organisms

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Understanding and facilitating healthy aging has become a major goal in medical research and it is becoming increasingly acknowledged that there is a need for understanding the aging phenotype as a whole rather than focusing on individual factors. Here, we provide a universal explanation for the emergence of Gompertzian mortality patterns using a systems approach to describe aging in complex organisms that consist of many inter-dependent subsystems. Our model relates to the Sufficient-Component Cause Model, widely used within the field of epidemiology, and we show that including inter-dependencies between subsystems and modeling the temporal evolution of subsystem failure results in Gompertizan mortality on the population level. Our model also provides temporal trajectories of mortality-risk for the individual. These results may give insight into understanding how biological age evolves stochastically within the individual, and how this in turn leads to a natural heterogeneity of biological age in a population.
OriginalsprogEngelsk
Artikelnummer1196
TidsskriftScientific Reports
Vol/bind14
Udgave nummer1
Antal sider11
ISSN2045-2322
DOI
StatusUdgivet - 2024

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© 2024. The Author(s).

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