Amelie Stein
Associate Professor
Computational and RNA Biology
Ole Maaløes Vej 5
2200 København N.
My lab studies the consequences of sequence variants on proteins, focusing on their cellular stability and function. We perform high-throughput assays on protein variants and build on this data to develop and improve methods for prediction of variant consequences. We then apply these methods to determine whether genomic variants are likely to be pathogenic. Further we aim to integrate effects of multiple mutations for applications in protein engineering.
ID: 144764550
Most downloads
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294
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Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
165
downloads
Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
98
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Co-Chaperones in Targeting and Delivery of Misfolded Proteins to the 26S Proteasome
Research output: Contribution to journal › Review › Research › peer-review
Published