The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na+/H+ exchanger NHE1
Research output: Contribution to journal › Journal article › Research › peer-review
Ischemic postconditioning (PostC), i.e. brief ischemia-reperfusion cycles before full reperfusion, is protective against cardiac ischemia/reperfusion (I/R) injury. Inhibition of the Na(+)/H(+) exchanger NHE1 and delayed intracellular pH-normalization have been proposed to underlie protection by PostC.
| Original language | English |
|---|---|
| Journal | Cellular Physiology and Biochemistry |
| Volume | 28 |
| Issue number | 1 |
| Pages (from-to) | 13-24 |
| Number of pages | 12 |
| ISSN | 1015-8987 |
| DOIs | |
| Publication status | Published - 2011 |
- Acids, Amiloride, Animals, Apoptosis, Cells, Cultured, Hydrogen-Ion Concentration, Ischemic Postconditioning, Male, Mitogen-Activated Protein Kinase 8, Mitogen-Activated Protein Kinase 9, Models, Biological, Myocardial Ischemia, Myocardial Reperfusion Injury, Myocytes, Cardiac, Necrosis, Neuroprotective Agents, Proto-Oncogene Proteins c-akt, Rats, Rats, Sprague-Dawley, Sodium-Hydrogen Antiporter, p38 Mitogen-Activated Protein Kinases
Research areas
ID: 45081170