– Niels Bohr Institute - University of Copenhagen

Single-cell Analysis of Lambda Immunity Regulation

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Documents

Kristoffer Torbjørn Bæk, Sine Lo Svenningsen, Harvey Eisen, Kim Sneppen, Stanley Brown

We have examined expression of the ¿cI operon in single cells via a rexgfp substitution. Although average fluorescence agreed with expectations for expression of ¿-repressor, fluorescence fluctuated greatly from cell-to-cell. Fluctuations in repressor concentration are not predicted by previous models and are tolerated in part by a regulatory response to DNA damage.
Original languageEnglish
JournalJournal of Molecular Biology
Volume334
Issue number3
Pages (from-to)363-372
Number of pages10
ISSN0022-2836
DOIs
Publication statusPublished - 2003

Bibliographical note

Keywords: bacteriophage lambda; repressor; GFP; single-cell analyses

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