Effect of membrane curvature on lateral distribution of membrane proteins

Research output: Other contributionResearch

Several membrane proteins exhibit interesting shapes that increases their preference for certain membrane curvatures. Both peripheral and transmembrane proteins are tested with respect to their affinity for a spectrum of high membrane curvatures. We generate high membrane curvatures by pulling membrane tubes out of Giant Unilamellar lipid Vesicles (GUVs). The tube diameter can be tuned by aspirating the GUV into a micropipette for controlling the membrane tension. By using fluorescently labled proteins we have shown that sorting of proteins like e.g. FBAR onto tubes is significantly increased for highly curved tubes (small tube diameter)
Original languageEnglish
Publication date2015
Publication statusPublished - 2015

ID: 150774625