Small RNA, a Novel Player in Gene Regulation – Niels Bohr Institute - University of Copenhagen

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Small RNA, a Novel Player in Gene Regulation

Since the introduction of the central dogma in molecular biology the transfer of sequence information from DNA into RNA and finally protein synthesis has been studied in great detail. It is thus well-known that the expression of a gene into its functional protein, is not set simply by the strength of the promoter in front of the gene. Gene expression is regulated both at the transcriptional and translational level, e.g. through transcription factors interfering with RNA polymerase binding.
Within the last decade a new feature of gene regulation has been identified in the translational regulation invoked by small RNAs  (sRNAs). sRNAs are pieces of non-coding RNA, typically 50-200 nt in size. More than 70 sRNAs have been identified in Escherichia coli.
In this colloquium the regulatory action of sRNAs is presented along with a simple kinetic model. Comparisons are made between model predictions and experimental data revealing novel modes of gene regulation.

Supervisor: Kim Sneppen